The Lazarus Effect: Experiments Restoring Cellular Activity After Death

Scientists at Yale University used BrainEx and OrganEx to restore perfusion and measure selected cellular, molecular, metabolic, electrical, contractile, and tissue-preservation endpoints in pig organs after prolonged interruption of circulation.

They did not restore an independently living animal, demonstrate consciousness, reverse brain death, or establish a treatment for humans.

This episode follows the 2019 BrainEx study of isolated pig brains perfused roughly four hours after death and the 2022 OrganEx study, in which anesthetized pigs underwent induced cardiac arrest, approximately one hour of warm ischemia, and six hours of specialized extracorporeal perfusion. What did the researchers actually observe? What remains unproven? And what happens when death is understood not as one instant, but as a sequence of biological failures occurring on different timelines?

This podcast uses artificial intelligence in its research, writing, production, and narration. Episodes are editorially reviewed before publication.

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YES OR NO: Did OrganEx restore an independently self-sustaining pig?