In this episode, Dr. Jockers sits down with neurologist and bestselling author Dr. David Perlmutter to explore microglia, the brain's immune cells, and the role they may play in protecting the brain from cognitive decline. You'll learn what can shift these cells from a supportive state toward one that promotes neuroinflammation.
Discover why your metabolic health and brain health are deeply connected. Dr. Perlmutter explains how blood sugar, insulin resistance, gut health, and chronic inflammation can influence microglial function and why addressing these factors may be important long before memory problems appear.
You'll also hear practical ways to support your brain through exercise, nutrition, sleep, metabolic flexibility, and other daily habits. Dr. Perlmutter shares why protecting your brain isn't just about what happens later in life—and how the choices you make today can help shape your cognitive future.
In This Episode:
00:00 Amyloid Myth Busted
00:15 Show Intro and Guest
04:18 Book Inspiration Microglia
06:02 Symptom Care vs Root Cause
09:51 Microglia M1 vs M2
11:15 Gut Brain Inflammation Link
15:01 Metabolism Mirrors Microglia
17:57 Infections Vaccines and Triggers
19:31 CTE Diabetes and Feedforward
25:20 New Tools and Beta Amyloid Drugs
30:37 Cochrane Verdict Drugs Fail
33:28 Lifestyle Trial Reverses Decline
38:23 Microglia Lifestyle Levers
39:07 Exercise Myokines Brain Boost
42:20 Alzheimers Risk Epigenetics
45:12 Imaging Microglia TSPO
46:24 Fasting Ketones Brain Fuel
49:45 MCT Oil Memory Care
51:16 POINTER Lifestyle Trial
55:57 Fiber Polyphenols Foods
58:34 Supplements DHA Vitamin D
01:02:23 Key Labs Glucose Tau
01:06:19 Prevention Mission Wrap
01:07:43 Final Thanks Outro
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"Exercise isn't just changing your body. It's changing the environment inside your brain."
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Resources:
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Enjoy 15% off grass-fed beef sticks with code DRJOCKERS at paleovalley.com/drjockers.
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Go to iRestore.com and use promo code DRJOCKERS
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Visit Superpower.com and use promo code JOCKERS to get $20 off
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Visit BUBSNaturals.com and use promo code DRJOCKERS to get 20% off
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If you are interested in being a guest on the show, we would love to hear from you! Please contact us here! - https://drjockers.com/join-us-dr-jockers-functional-nutrition-podcast/
