This episode is brought to you by One Skin, Puori, Fatty15, and Our Place.
Today on The Dhru Purohit Show, I sit down with Dr. David Perlmutter to explore why decades of brain health research may have focused on the wrong target. We dive into why microglial cells, not beta-amyloid, may be key drivers of cognitive decline, how they’re connected to metabolic health, and what you can do to protect your brain. Dr. Perlmutter also shares why many Alzheimer’s drugs miss the mark, the supplements with the strongest evidence, and the lifestyle habits you can start today to support your cognitive health for years to come
Dr. David Perlmutter is a board-certified neurologist, Fellow of the American College of Nutrition, and six-time New York Times bestselling author, best known for Grain Brain and Drop Acid. He earned his M.D. from the University of Miami School of Medicine, where he received the Leonard G. Rowntree Research Award, and currently serves as an Associate Professor at the University of Miami Miller School of Medicine. Dr. Perlmutter has published extensively in leading peer-reviewed medical journals, serves on the Editorial Board of the Journal of Alzheimer's Disease, and lectures worldwide on brain health, nutrition, and longevity.
In this episode, Dhru and Dr. Perlmutter dive into:
(0:00) The Biggest Mistake in Brain Health
(3:09) The Brain Cells That Control Your Future
(5:01) Why Microglia Are Suddenly Everywhere
(8:41) Dr. Perlmutter’s Controversial Claim
(11:51) Decline May Begin Decades Earlier
(21:36) When Your Brain's Defenders Turn Against You
(23:38) The Gut-Brain Connection
(38:51) The Hidden Chemical Linked to Damage
(41:58) Why Modern Life Is Rewiring Your Brain
(45:30) Are Microplastics Harming Your Brain?
(49:05) The Best Forms of Exercise
(59:37) The Key Biomarkers
(1:03:51) The Brain-Protective Diet
(1:16:04) Top Supplements to Support Brain Health
(1:22:49) Building a Resilient Brain
(1:31:08) Has the Science on Alcohol Changed?
(1:36:38) What to Do If You're Already at Risk
(1:43:13) Could GLP-1s Protect the Brain?
(1:51:55) Final Thoughts
Also mentioned in this episode:
Brain Defenders: Harness the Power of Your Immune Cells to Protect Your Brain for Life
Lichen Air
For more on Dr. Perlmutter, follow him on Facebook, X/Twitter, Instagram, YouTube, or visit his Website.
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